Flossie Wong-Staal, a molecular virologist most famous for co-discovering and first cloning the human immunodeficiency virus (HIV) that causes AIDS, died July 8 of complications from pneumonia in La Jolla, California, at age 73.
Wong-Staal arrived at the National Cancer Institute (NCI) in 1973 as a postdoctoral researcher in the lab of fellow virologist Robert Gallo, where she quickly became an essential contributor to the team’s work studying retroviruses. Together, Gallo and Wong-Staal published more than 100 papers in 20 years, according to an article by the NCI, and a 1990 article in The Scientist credits her as being the most-cited woman in science during the 1980s, earning 7,772 citations in academic journals. Wong-Staal was inducted into the National Women’s Hall of Fame last year for her contributions to the field.
During her time in Gallo’s lab, Wong-Staal was part of the group that identified the first human retrovirus, human T-cell leukemia virus type 1 (HTLV-1), and showed that it could cause cancer. While it was already known that retroviruses replicated by inserting their genetic material directly into the genome of their hosts, scientists of the day were skeptical that these viruses could cause cancer in humans. “At the time, the dogma was that [human tumor viruses] did not exist,” Wong-Staal said in a 1997 oral history, adding that the lab was often criticized in its search for “rumor viruses.”
In the early 1980s, when AIDS cases first began appearing in alarming numbers, Wong-Staal was uniquely poised to study the emerging epidemic—HIV, the virus that causes the disease, turned out to be a retrovirus. A team led by Gallo shared the co-discovery of HIV with the French scientist Luc Montagnier, and Wong-Staal provided the molecular evidence needed as proof. In 1985, she would become the first person to clone HIV and begin studying the functions of its genes, a necessary step towards developing eventual treatments.
Credit : Scientist
Picture Credit : Google
