The first vaccine for cholera was developed in the late 19th century. It became the first widely used vaccine ever made in a laboratory. In 1885, Jaume Ferran i Clua developed an early version of this with a live vaccine he isolated from cholera sufferers in Marseilles.
Waldemar Haffkine later developed another cholera vaccine with milder side effects and tested it in Calcutta between 1893 and 1896.
The first heat-killed cholera vaccine was developed by Wilhelm Kolle in 1896. Much easier to make, Kolle’s vaccine was used on a large scale in Japan in 1902. Recognized by the WHO as an essential medicine, cholera vaccine has become important for us.
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